Today, perhaps, any woman who cares about her appearance has heard of mesotherapy. Reviews about this technique are very different – from “did not notice the effect” to “this is great!”. All this is said in connection with the solution of cosmetic problems. However, mesotherapy was not born at all as a procedure of cosmetologists, although, of course, today they are most often used.
In 1952, the French general practitioner Michelle Pistor introduced the patient to the parotid region to relieve pain anesthetic procaine, and, after a while, was surprised to note a partial improvement in hearing. Over the following years, he carefully studied the revealed causal relationship and wrote several monographs on this subject. In the 60s, a special Lebel needle was created, familiar to all mesotherapists today, which, interestingly, was created in collaboration with veterinarians. By the way, the first patients who experienced mesotherapy were pets. Today, mesotherapy is practiced in every self-respecting medical and aesthetic salon.
What? How? Where to?
The word “mesotherapy”, like many medical terms, is of Greek origin (“meso” – middle, median, “therapy” – treatment). And to begin the explanation of the mechanism of action is that during the intrauterine development of the embryo, at a certain stage, three layers can be distinguished: ectoderm, mesoderm and endoderm. It is from the mesoderm that bones, cartilage, muscles, adipose and connective tissue develop later. And the skin is for the most part and consists of connective tissue. It follows that by influencing the components of the dermis, you can change the condition and appearance of the skin and even affect other target organs located quite far from the skin.
One side of the mesotherapy positive effect mechanism is pharmacokinetics – biodistribution, metabolism (chemical transformations), excretion (excretion period), which differ significantly from those with other routes of drug administration. In particular, it is said about the locality of drug administration to a depth of 0.5 – 3 mm. With this introduction, a kind of reservoir is created, from where the drug is transported not only through the system of blood and lymph capillaries, but also by diffusion through tissue fluid. It is believed that in this way substances reach the target much faster, and their concentration remains at a high level for a long time. This allows you to increase the time intervals between administration sessions compared with intravenous or intramuscular administration. After all, we remember that mesotherapy is not only a method of improving the condition of the skin, but also a method of treating internal diseases.
Mesotherapists affirm the three main principles of this technique “little, rarely, in the right place.”
The other side is that an effective effect can be exerted through receptors located remotely, since the entire surface of any cell is equipped with receptors – points of biochemical activity. Next, an intercellular communication system is activated – various signaling molecules acting at a distance and transmitting a signal to neighboring cells. In this way, local, regional and systemic effects of the administered drugs are ensured.
Another point is that multiple superficial injections have an additional effect, connecting reflexology mechanisms, the very irritation from the introduction of the needle stimulates non-specific factors of immunity, and hence improves the condition of the tissue.
What we treat
The best results, as practice shows, can be achieved using mesotherapy in various fields of medicine: rheumatology and traumatology (relief of inflammation and pain), in the treatment of infectious diseases (tonsillitis, sinusitis), and vascular pathologies (chronic venous insufficiency, trophic ulcers) . Of course, mesotherapists come to the rescue in many cases of skin diseases – acne, eczema, flat warts. And amazingly, excellent results are also achieved in uro-gynecology (inflammatory diseases, enuresis, impotence), gastroenterology (dysphagia, gastritis), neurology (headaches, spasticity), with neurosis, depressive states, sleep disorders, and the effects of stress.
However, the most widespread mesotherapy has been achieved in solving aesthetic problems that are usually divided into body mesotherapy: cellulite, excess body fat, and face mesotherapy: prevention and treatment of skin aging, mesolifting, atrophic, hypertrophic and keloid scars, rosacea, oily, porous skin, acne outside the stage of exacerbation, preparation and rehabilitation after surgery, chemical, mechanical peeling, laser resurfacing of the skin. However, many of these procedures can well be attributed to both body and face therapy, plus work with alopecia (baldness). So the range of problems to be solved is quite large.
How to enter
The very first method of introducing drugs into the skin is, of course, manual using a needle.